Telomeres and Telomerase: Their Implications in Human Health and Disease
Elizabeth Blackburn, June 2008
University of California, San Francisco/Department of Biochemistry and Biophysics		 Next Part
Lecture Overview
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.
Part 1: The Roles of Telomeres and Telomerase (48:27)

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    • Part 2: Telomeres and Telomerase in Human Stem Cells and in Cancer (26:58)

     


    Part 3: Stress, Telomeres and Telomerase in Humans (45:58)




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