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Review QuestionsThe molecular processes of actin-based motility are highly conserved; list three examples of actin-based motility in eukaryotic cells. During cell motility, why is it necessary to coordinate front protrusion and rear retraction with the formation of adhesive surface contacts? Explain how nucleotide binding influences actin dynamics (ATP vs. ADP bound actin). Why is Listeria movement through the host cytosol more impressive than a submarine moving through the ocean? What are two models for opening space to allow actin monomer insertion between a filament tip and a load during actin-based force generation? Given the information presented in the lecture, what effect would increasing or decreasing temperature have on force generation at the leading edge during actin-based motility? Compare the molecular cytoskeletal events of leading edge protrusion with actin-based motility of Listeria. How would you design an experiment to determine if Listeria ActA is the only bacterial protein necessary for actin-based motility?
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