Cytoskeletal Motor Proteins Ron Vale, July 2007 HHMI /Dept of Cellular and Molecular Pharmacology, University of California, San Francisco

Lecture Overview The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials.		Part 3: Mining the Genome for Mitotic Treasures (33:41) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format*   QuickTime 7 Required    *640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats: (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (63mb)     MP4 (387mb)     iPod/iPhone Video (387mb) PowerPoint Slides 1/page (2.2mb)     PowerPoint Slides 6/page (1.9mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 1: Introduction to Motor Proteins (43:13)   Part 2: Single Molecule Approaches for Understanding Molecular Motors (25:20) Speaker Bio   Related Articles